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An extensive literature on haloperoxidases supports the broad microbicidal
activity of myeloperoxidase (MPO) and eosinophil peroxidase (EPO). A list
of selected articles, arranged by topic, follows.
Myeloperoxidase
- Klebanoff SJ. Phagocyte antimicrobial systems: Myeloperoxidase. Proceedings
of the Association of American Physicians 1999, 111, 5, 383-389.
- Winterbourn CC, Vissers MCM, Kettle AJ. Myeloperoxidase. Current
Opinion in Hematology 2000, 7, 53–58.
Eosinophil Peroxidase
- Bolscher BG, Plat H, Wever R. Some properties of human eosinophil
peroxidase, a comparison with other peroxidases. Biochim Biophys Acta
1984, 784, 177-186.
- Jong EC, Henderson WR, Klebanoff SJ. Bactericidal activity of eosinophil
peroxidase. J Immunol 1980, 124, 1378-1382.
- Van Dalen CJ, Kettle AJ. Substrates and products of eosinophil peroxidase.
Biochem. J. 2001, 358, 233-239.
Mechanism of Action
- Furtmuller PG, Obinger C, Hsuanyu Y, Dunford HB. Mechanism of reaction
of myeloperoxidase with hydrogen peroxide and chloride ion. Eur. J.
Biochem. 2000, 267, 5858-5864.
- Chika, K., Makiuchi, M., Miyazaki, J., Fujinaga, T., and Kakinuma,
K. Physiological production of singlet molecular oxygen in the myeloperoxidase-H202-chloride
system. FEBS Letters 1999, 443, 154-158.
- Allen RC. The role of pH in the chemiluminescent response of the
MPO halide HOOH antimicrobial system. Biochem Biophys Res Comm 1975,
63, 684-691.
- Kanofsky JR, Wright J, Miles-Richardson GE, Tauber AI. Biochemical
requirements for singlet oxygen production by purified human myeloperoxidase.
J Clin Invest 1984, 74, 1489-1495.
- Kanofsky JR, Hoogland H, Wever R, Weiss SJ. Singlet oxygen production
by human eosinophils. J Biol Chem 1988, 263, 9692-9696.
- Tatsuzawa, H., Maruyama,T., Hori, K., Sano, Y., and Nakano, M. Singlet
oxygen as the principal oxidant in myeloperoxidase-mediated bacterial
killing in neutrophil phagosome. Biochem. Biophys. Res. Commun. 1999,
262, 647-650.
Antimicrobial Activity
- Allen RC. Role of oxygen in phagocyte microbicidal action. Environ
Health Perspect 1994, 102, Suppl 10, 201-208.
- Borelli V, Banfi E, Perrotta M G, Zabucchi G. Myeloperoxidase Exerts
Microbicidal Activity against Mycobacterium tuberculosis. Infection
and Immunity 1999, 67, 4149–4152.
- Chochola J, Yamaguchi Y, Moguilevsky N, Bollen A, Strosberg AD, Stanislawski
M. Virucidal effect of myeloperoxidase on human immunodeficiency virus
type 1-infected T cells. Antimicrob Agents Chemother. 1994, 38, 5, 969-972.
- Marodi L, Tournay C, Kapostzta R, Johnston RB, Moguilevsky N. Augmentation
of human macrophage candidacidal capacity by recombinant human myeloperoxidase
and granulocyte-macrophage colony-stimulating factor. Infect Immun.
1998, 66, 6, 2750-2754.
- Washburn RG, Gallin JL, Bennett JE. Oxidative killing of Aspergillus
fumigatus proceeds by parallel myeloperoxidase-dependent and -independent
pathways. Infect Immun 1987, 55, 2088-2092.
- Wright CD, Nelson RD. Candidacidal activity of myeloperoxidase: characterization
of myeloperoxidase-yeast complex formation. Biochem Biophys Res Commun
1988, 47, 522-525.
- Yang Y, Anderson E.J. Antimicrobial activity of a porcine myeloperoxidase
against plant pathogenic bacteria and fungi Journal of Applied Microbiology
1999, 86, 211–220.
- Messaoudi K. El, Verheyden A-M, Thiry L, Fourez S, Tasiaux N, Bollen
A, Moguilevsky N. Human Recombinant Myeloperoxidase Antiviral Activity
on Cytomegalovirus. Journal of Medical Virology 2002, 66, 218-223.
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